GDNF for Parkinsons is an infusion of recombinant proteins that support neuron survival and growth. GDNF is a powerful treatment for Parkinsons because it supports the survival of motor and dopaminergic neurons.
You cannot find buy GDNF (Glial-Derived Neurotrophic Factor) as an over the counter supplement. It is a large protein that does not cross the blood-brain barrier easily. You will be able to find natural compounds and herbs as supplements that are designed to boost the body’s production of GDNF. These include, for example, Ashwagandha, Green Tea, Ginseng and Vitamin D3 (the sunshine vitamin).
The most effective and reliable way to infuse the brain with GDNF is with regular exercise. This in large part is why so many persons who have Parkinson’s symptoms discover regular exercise to be a most effective way to celebrate symptom relief. Supplements formulated to encourage the body to manufacture GDNF are not needed with a regular exercise regimen.
The study abstract that follows recommends using a combined approach of multimodal exercises to include 1. resistance 2. aerobic and 3. balance is recommended as the most effective strategy for facilitating the natural production of GDNF by the body
Int J Prev Med. 2025 May 28:16:35. The Effect of Multimodal Exercise on the Levels of BDNF and GDNF in Patients with Parkinson’s Disease.
Abstract
Background: Parkinson’s disease (PD) leads to a significant decrease in brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). This study explores the effect of 12 weeks of multimodal exercise on the levels of BDNF and GDNF in patients with PD.
Methods: The study is a quasiexperimental study with random sampling. It was conducted in 2024 at Isfahan. Demographic data were collected using a demographic questionnaire. Thirty patients were randomly divided into two equal groups of multimodal exercise and control, with no significant differences in age, weight, and height. The variables of BDNF and GDNF were assessed in pre- and post-tests. Multimodal exercise was performed 5 days a week for 12 weeks. Data were analyzed using covariance and t-test at a significant level of P < 0.05.
Results: The study observed significant differences in BDNF and GDNF, among two groups of PD (P < 0.01). Moreover, the levels of BDNF and GDNF were significantly higher in the PD + Training group compared to the PD group (P < 0. 01).
Conclusions: Given that multimodal exercises are effective in increasing BDNF and GDNF in individuals with PD, it is recommended to incorporate the benefits of these exercises into physical rehabilitation programs. Therefore, the combined approach of multimodal exercises (resistance, aerobic, and balance) is recommended as the most effective complementary therapeutic strategy for PD.
Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
Road to Recovery from Parkinsons Disease



