Cause of Parkinson’s Disease

What is the cause of Parkinson’s disease symptoms? Are toxins an issue? Many people I have interviewed report their doctor concluded toxins were not an issue for them after doing FDA approved tests. If you have concluded toxins are not an issue for you, please listen to this interview clip.

Dr. Joe Hickey, MD, discusses the approach he uses in his practice to treat symptoms of Parkinsons disease. Many standard medical tests do not detect the presence of toxins embedded in the tissues and organs of the body. He explains in this clip of my interview with him in 2011 the correct way to assess the presence of toxins and how to eliminate them.

It may come as a surprise to discover that toxins are primarily lodged in the bones.

Research summarized below report environmental toxins are triggers for development of Parkinson’s Disease.  Examples of toxins as the cause of Parkinson’s are well documented such as lead, copper,.aluminum, manganese, Carbon Monoxide poisoning, Carbon DiSulfide from the Rayon Industry and MPTP.

Toxins and Parkinson’s Disease

Environmental factors have garnered increasing attention for their potential contribution to symptoms of Parkinson’s.  Among these factors, exposure to certain toxins has emerged as a primary area of investigation. Various industrial chemicals, pesticides, heavy metals, and pollutants have been implicated in increasing the risk of developing Parkinson’s disease.

Pesticides: One group of toxins that has drawn considerable scrutiny in relation to Parkinson’s is pesticides. Studies have shown that individuals exposed to certain pesticides, such as paraquat and rotenone, have an elevated risk of developing PD. These chemicals are known to interfere with cellular mechanisms involved in dopamine regulation and neuronal function, potentially contributing to neuro-degeneration.

Heavy Metals:  Lead and manganese have also been implicated in the pathogenesis of PD. Chronic exposure to these metals, often through occupational settings or environmental pollution, can lead to the accumulation of toxic levels in the brain. This accumulation may trigger oxidative stress, inflammation, and mitochondrial dysfunction, all of which are implicated in the neurodegenerative processes.

Air Pollution: Evidence shows a link between exposure to air pollutants and an increased risk of Parkinson’s. Particulate matter, ozone, and other air pollutants can penetrate the blood-brain barrier, eliciting neuro inflammatory responses and oxidative stress, both of which contribute to neuronal damage.

Below is an abstract of the study Dr. Hickey referenced during my interview with him.

Neurotoxicology. 1993 Summer-Fall;14(2-3):225-36. Lead in bone: storage site, exposure source, and target organ. E K SilbergeldJ SaukM SomermanA ToddF McNeillB FowlerA FontaineJ van Buren


The primary site of lead storage is in bone but relatively little attention has focused on this physiological compartment. Recent advances in measurement technology now permit the direct in vivo quantitative measurement of lead in bone, and this measure has great use in clinical and epidemiologic studies.

Lead in bone is not a physiological sink, but can be mobilized back into the circulation in response to normal or pathological changes in mineral metabolism. Bone lead may be a significant source of target organ exposure under certain conditions, such as pregnancy, kidney disease, and menopause. Finally, the accumulation of lead in bone cells may have toxic consequences for bone status, and some of the mechanisms by which lead could affect bone mineral metabolism may also play a role in other target organ effects of lead.

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