Parkinsons Recovery is dedicated to identifying promising new therapies that offer the promise of reversing symptoms of Parkinson’s disease. One such
therapy, High-Dose Thiamine, was discussed today on Parkinsons Recovery Radio by Italian neurologist Antonio Constantini MD. He has been prescribing High Dose Thiamine as a treatment for his Parkinson’s patients with good success. Click on the pointer to hear the replay.
Brief Summary of the Q&A Follows
What Results have Your Parkinson’s Patients Experienced?
It depends in part on whether the person has been recently experienced symptoms of Parkinson’s or has had them for several years. For the newly diagnosed taking high dose thiamine (whether by oral tablet or injection) reduces motor symptoms on average by 50% to 70% for persons who have recently begun experiencing Parkinson’s symptoms. In selected cases a patient can celebrate experiencing no symptoms. Improvements in motor symptoms are common.
For patients who have experienced symptoms for a long period of time, Dr.Costantini prescribes L-dopa and other more traditional medications. Such patients are also reported to experience symptom relief but results are generally not as dramatic.
How “High” Does the Thiamine Dosage Need to Be?
The recommended dosage varies considerably from patient to patient and is determined only after a medical checkup. Many factors influence the dosage that is prescribed. Possibilities range from 1 gram up to 4 grams a day of Vitamin B1 which is 1,000 to 4,000 times the normally recommended dose.
For some patients requiring the higher doses Dr. Costantini may administer B1 injections of 100 milligrams twice a week for a total intake of 200 milligrams each week of treatment.
Why Do You Prescribe High Dose Thiamine for your Parkinson’s Patients?
When there is a deficiency of thiamine, the result is a dysfunction in
metabolism. For persons experiencing Parkinson’s symptoms, Dr. Costantini hypothesized there is a deficiency in the update of thiamine to the brain cells that produce dopamine.
How Quickly Do Parkinson’s Patients Begin to Experience Relief from Symptoms?
If they are taking Thiamine in tablet or powder form, it typically takes 2-3 days to experience symptomatic improvement. When shots or injections are administered the improvement can typically be experienced in 30-45 minutes.
Once a patient begins taking high dose thiamine Dr. Costantini reports that they typically must continue taking it to receive continued benefits. It is possible to take short breaks without incurring troublesome setbacks.
What Conditions Other the Parkinson’s Is High Dose Thiamine Therapy Useful?
Dr. Costantini reports that high dose thiamine is also useful for chronic fatigue, fibromyalgia, cluster headaches, migraines and Huntington’s disease.
Robert Rodgers PhD
Road to Recovery from Parkinsons Disease