Parkinsons Recovery is dedicated to identifying promising new therapies that offer the promise of reversingÂ symptoms of Parkinson’s disease. One such
therapy, High-Dose Thiamine, Â was discussed today onÂ Parkinsons Recovery Radio by Italian neurologist Antonio Constantini MD. Â He has been prescribing High Dose ThiamineÂ as a treatment for his Parkinson’s patients with good success. Â Click on the pointer to hear the replay.
Brief Summary of the Q&A Follows
What Results have Your Parkinsonâ€™s Patients Experienced?
It depends in part on whether the person has been recently experienced symptoms of Parkinson’s or has had them for several years. For the newly diagnosed taking high dose thiamine (whether by oral tablet or injection)Â reduces motor symptoms on average by 50% to 70% for persons whoÂ have recently begun experiencing Parkinson’s symptoms. In selectedÂ cases a patient can celebrate experiencing no symptoms. ImprovementsÂ in motor symptoms are common.
For patients who have experienced symptoms for aÂ long period of time, Dr.Costantini prescribes L-dopa andÂ other more traditional medications. Such patientsÂ are also reported to experience symptom relief but results are generally not as dramatic.
How “High” Does the Thiamine Dosage Need to Be?
The recommended dosage varies considerably fromÂ patient to patient and is determined only after a medical checkup. Many factors influenceÂ the dosage that is prescribed. Possibilities range from 1 gram up toÂ 4 grams a day of Vitamin B1 which is 1,000 toÂ 4,000 times the normally recommended dose.
For some patients requiring the higherÂ doses Dr. Costantini may administer B1 injectionsÂ of 100 milligrams twice a weekÂ for a total intake of 200 milligrams each week of treatment.
Why Do You Prescribe High Dose Thiamine for your Parkinson’s Patients?
When there is a deficiencyÂ of thiamine, the result is a dysfunction in
metabolism. For persons experiencing Parkinson’sÂ symptoms, Dr. Costantini hypothesized thereÂ is a deficiency in the update of thiamine toÂ the brain cells that produce dopamine.
How Quickly Do Parkinson’s Patients Begin to Experience Relief from Symptoms?
If they are takingÂ Thiamine in tablet or powder form, itÂ typically takes 2-3 days to experienceÂ symptomatic improvement. When shots or injectionsÂ are administered the improvement can typicallyÂ be experienced in 30-45 minutes.
OnceÂ a patient begins taking high dose thiamineÂ Dr. Costantini reports that they typicallyÂ must continue taking it to receive continuedÂ benefits. It is possible to take shortÂ breaks without incurring troublesome setbacks.
What Conditions Other the Parkinson’s Is High Dose Thiamine Therapy Useful?
Dr. Costantini reports that high doseÂ thiamine is also useful for chronicÂ fatigue, fibromyalgia, cluster headaches, migraines and Huntington’s disease.
Robert Rodgers PhD
Road to Recovery from Parkinsons Disease