Listen to discover the findings of recent Parkinson’s studies which have identified the strong correlation between insulin resistance and a diagnosis of Parkinson’s disease.

If you are challenged with gut issues and insulin resistance, what natural remedies might be helpful? Taking insulin might well be beneficial but that would be a prescription medicine option. What are the natural options that might be embraced? Listen to my brief set of suggestions below where I lay out a few options to consider.

Interested in mangosteen as an option to take seriously? Below I have included information about mangosteen and the recent research which suggests it is an option worth taking seriously.

There are obviously a number of different sources of mangosteen which has proven to have a wide variety of health benefits.

Watch a short video below which discusses a mangosteen product developed by CTFO (Changing the Future Outcomes). If you get high potency mangosteen and it does not offer symptom relief, you can return the empty bottle to claim a 100% refund plus shipping. I suggest this as a possibility because it is a no risk option to consider. You of course may well have other options to acquire mangosteen. The mangosteen described below should provide the best option to see if it may help address the issue of insulin resistance.

YouTube player

Click the link below with information about the Zanthomyst (mangosteen) product.

Research on Mangosteen and Insulin Resistance

The study below uses rats which is the standard protocol used by researchers. Human studies are seldom launched until studies using animals demonstrate effectiveness. It will likely be another 5-10 years before studies with human subjects are published.

Pharm Biol. 2023 Dec;61(1):241-248. Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model. Vivian Soetikno , Prisma Andini , Miskiyah Iskandar , Clark Christensen Matheos , Joshua Alward Herdiman , Iqbal Kevin Kyle , Muhammad Nur Imaduddin Suma , Melva Louisa , Ari Estuningtyas

Context: ?-Mangosteen (?-MG) attenuates insulin resistance (IR). However, it is still unknown whether ?-MG could alleviate hepatic manifestations in IR rats.

Objective: To investigate the effect of ?-MG on alleviating hepatic manifestations in IR rats through AMP-activated protein kinase (AMPK) and sterol-regulatory element-binding protein-1 (SREBP-1) pathway.

Methods: IR was induced by exposing male Sprague-Dawley rats (180-200 g) to high-fat/high-glucose diet and low-dose injection of streptozotocin (HF/HG/STZ), then treated with ?-MG at a dose of 100 or 200 mg/kg/day for 8 weeks. At the end of the study (11 weeks), serum and liver were harvested for biochemical analysis, and the activity of AMPK, SREBP-1c, acetyl-CoA carboxylase (ACC), tumor necrosis factor (TNF)-?, interleukin (IL)-1?, IL-6, insulin receptor substrate (IRS)-1, Bax and liver histopathology were analyzed.

Results: ?-MG at both doses significantly lowered ALT, AST, triglyceride, and cholesterol total by 16.5, 15.7, 38, and 36%, respectively. These beneficial effects of ?-MG are associated with the downregulation of the IR-induced inflammation in the liver. Furthermore, ?-MG, at both doses, activated AMPK by 24-29 times and reduced SREBP-1c by 44-50% as well as ACC expression by 19-31% similar to metformin. All treatment groups showed liver histopathology improvement regarding fat deposition in the liver.

Conclusions: Based on the findings demonstrated, ?-MG protected against HF/HG/STZ-induced hepatic manifestations of the IR rats, at least in part via the modulation of the AMPK/SREBP-1c/ACC pathway and it could be a potential drug candidate to prevent IR-induced hepatic manifestations.

Int J Mol Sci. 2020 Aug 27;21(17):6211. Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles. Ha Thi Thu Do, Jungsook Cho

Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression are growing burdens for society globally, partly due to a lack of effective treatments. Mangosteen (Garcinia mangostana L.,) pericarp (MP) and its xanthones may provide therapeutic advantages for these disorders. In this review, we discuss potential therapeutic value of MP-derived agents in AD, PD, and depression with their pharmacokinetic and safety profiles.

MP-derived agents have shown multifunctional effects including neuroprotective, antioxidant, and anti-neuroinflammatory actions. In addition, they target specific disease pathologies, such as amyloid beta production and deposition as well as cholinergic dysfunction in AD; ?-synuclein aggregation in PD; and modulation of monoamine disturbance in depression. Particularly, the xanthone derivatives, including ?-mangostin and ?-mangostin, exhibit potent pharmacological actions. However, low oral bioavailability and poor brain penetration may limit their therapeutic applications. These challenges can be overcome in part by administering as a form of MP extract (MPE) or using specific carrier systems. MPE and ?-mangostin are generally safe and well-tolerated in animals. Furthermore, mangosteen-based products are safe for humans. Therefore, MPE and its bioactive xanthones are promising candidates for the treatment of AD, PD, and depression. Further studies including clinical trials are essential to decipher their efficacy, and pharmacokinetic and safety profiles in these disorders.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.