Vitamin D3 recommendation as treatment for Parkinsons is reported in two recent studies. Abstracts are posted below.

These recent studies find that vitamin D3 plays a the pivotal role in preventing – as well as treating – symptoms associated with Parkinsons. Sunshine is a primary source of Vitamin D3, so bathing in the sun is therapeutic. Supplementation is an alternative treatment during the dreary winter months.

While there are dozens of recommendations of supplements that help offer relief from symptoms of Parkinsons, consider placing D3 at the top of your list of vitamins researchers now recommend.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®

Studies that Document a Relationship between D3 and Parkinsons

Adv Exp Med Biol. 2026:1493:51-67. Vitamin D and Brain Health

Abstract

Vitamin D is widely known for its influence on the homeostasis of calcium and phosphate levels in the body and its involvement in maintaining musculoskeletal health. This vitamin has immunomodulatory effects on both the innate and adaptive immune systems. The active form of vitamin D plays a neuroprotective role in the central nervous system, highlighting its importance in maintaining brain health.

Studies have noted the role of vitamin D in the formation of antioxidants, reduction of pro-inflammatory cytokines, lowering of oxidative stress, improvement of mitochondrial respiratory health, and slowing of the progression of neuronal damage.

This vitamin may also influence development by facilitating the differentiation of cells, the expression of neurotrophic factors, the regulation of cytokines, the synthesis of neurotransmitters, intracellular calcium signaling, and the expression of genes involved in neuronal differentiation.

An association has been noted between vitamin D deficiency and the risk of developing several neuronal diseases, including Parkinson’s disease, headaches, multiple sclerosis, and Alzheimer’s disease. The neuroprotective role of vitamin D suggests the potential benefit of vitamin supplementation in slowing the progression of such conditions and promoting brain health.

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Curr Pharm Des.  2024;30(5):323-332. Vitamin D as a Modulator of Neuroinflammation: Implications for Brain Health

Abstract

Neuroinflammation represents a critical immune response within the brain, playing a pivotal role in defense against injury and infection. However, when this response becomes chronic, it can contribute to the development of various neurodegenerative and psychiatric disorders.

This bibliographic review delves into the role of vitamin D in modulating neuroinflammation and its implications for brain health, particularly in the context of neurological and psychiatric disorders.

While vitamin D is traditionally associated with calcium homeostasis and bone health, it also exerts immunomodulatory and neuroprotective effects within the central nervous system. Through comprehensive analysis of preclinical and clinical studies, we uncover how vitamin D, acting through its receptors in glial cells, may influence the production of proinflammatory cytokines and antioxidants, potentially mitigating the cascade of events leading to neuronal damage.

Clinical research has identified vitamin D deficiency as a common thread in the increased risks of multiple sclerosis, Parkinson’s disease, Alzheimer’s, and depression, among others. Furthermore, preclinical models suggest vitamin D’s regulatory capacity over inflammatory mediators, its protective role against neuronal apoptosis, and its contribution to neurogenesis and synaptic plasticity.

These insights underscore the potential of vitamin D supplementation not only in slowing the progression of neurodegenerative diseases but also in improving the quality of life for patients suffering from psychiatric conditions.

Neuroinflammation is a crucial immune response in the brain against injuries or infections, but its persistence can lead to diseases such as Alzheimer’s, Parkinson’s, multiple sclerosis, and depression. Cholecalciferol (Vitamin D3) emerges as a regulator of neuroinflammation, present in brain cells such as astrocytes and microglia, modulating immune function. Vitamin D’s mechanisms of action include cytokine modulation and regulation of nuclear and mitochondrial genes. It adjusts inflammatory mediators and antioxidants, resulting in neuroprotective effects.

Additionally, vitamin D impacts neurotransmitter synthesis and brain plasticity. This positions vitamin D as a potential adjunct in treating diseases like Alzheimer’s and Parkinson’s. Lastly, its role in intestinal microbiota and serotonin synthesis contributes to psychiatric disorders like schizophrenia and depression. Thus, vitamin D presents a novel therapeutic approach for neuroinflammatory, neurodegenerative, and neuropsychiatric diseases.